I’m Matt Mireles.

I build technology to push the human race forward.

I have taught sand to think.
I have resurrected the dead.

I’m currently advising, investing, and exploring. Let’s talk.

From unlikely beginnings, I learned to speak human and machine — to design interfaces that feel like natural extensions of us, to create symbiotic machines.

This wasn’t fate; it was an act of will.

Before I ever wrote a line of code, I was a 911 paramedic in Harlem and the South Bronx. I did CPR on babies while their mothers screamed in my ear. I resurrected junkies found crumpled in the trash. I rescued bullet-ridden drug dealers as neighborhood kids stole their shoes and emptied their pockets like piranhas.

During the week, I was a Columbia University undergrad. On weekends, I was a cowboy 911 paramedic. That double life — Ivy League intellectualism by day, raw street medicine by night — shaped everything that came next.

Since then, I’ve founded three startups:

• SpeakerText (2008): A hybrid AI–human transcription platform acquired by CloudFactory in 2012, after raising from Google Ventures and Mitch Kapor.

• Dishcraft Robotics (2015): Robotic dishwashers powered by low-cost arms and computer vision. Raised $50M from Baseline, First Round Capital, and others.

• OASIS (2019): A frontier AI company that built real-time, on-device avatar video and a low-bandwidth video chat protocol. We raised $13M from Founders Fund, Naval Ravikant, Cyan Banister, and others. After physically melting iPhones and burning Sam Altman’s hand, we pivoted to TalkTastic and created voice-first AI interfaces users described as a “dial-up Neuralink.”

These days, I’m exploring what’s next. One idea: an AI health companion that listens deeply, remembers everything, and helps people live longer, healthier lives. Another: a better way to read and learn using eyes and ears together.

The throughline is transcendence through technology. I am obsessed with human thriving in the the age of superintelligent machines. 

I write Accelerate or Die, a newsletter about AI and the future of humanity — through the lens of evolutionary biology, history, economics, and religion. It reaches 19,000+ readers, including many influential technologists and more than a few billionaires.

Earlier in life, I was a journalist for The New York Times and Newsweek. I won the Eric Breindel College Journalism Award for a story about an Iraq War vet at Columbia. That $10,000 prize kept me from dropping out.

I’ve fought forest fires in Alaska, dropped out of college (twice), and lived a dozen lives. The throughline is simple: I do epic things that matter. I write. I fight. I think deeply. I help others do the same.

The story continues.

I’m a venture capitalist in my spare time.

Through my personal vehicle, Guerrilla Capital, I’ve invested in 30+ startups building radical technologies for the benefit of all mankind.

Civilizational Thriving

• Monumental Labs  Robot factory for stone sculptures & building facades
• Kinside (acquired by Urban Sitter): Finding childcare should be easy 
• Nuvocargo.  Transform your North America supply chain for the age of AI
• Shipamax (acquired by Wisetech Global): AI for global logistics
• Unspun  Robot factories for fashion clothing manufacturing
• Ava Labs ($AVAX): Fast, cheap layer-1 blockchain

Reversing Climate Change

• Crusoe  Carbon-negative GPU cloud powering OpenAI’s Stargate
• C16 Bio  Organic replacement for palm oil that you brew like beer
• Living Carbon  Trees engineered to maximize carbon capture
• Terraformation  Low-cost, technology-enabled forest restoration
• Carbon Collective  Climate-aligned stock & bond portfolios
• Heimdal  Rocks engineered to capture carbon directly from the air. 

Empowering Humans

• Adaract  Synthetic muscle fibers for robotic human augmentation
• Metavoice  AI voice skins for everyone
• The Beans  Personal finance automation for normies
• Unbound  Sex toys for female empowerment
• Blume  Feminine self-care for teens
• Oxygen  Neobank for gig workers
• NotEvil.ai: First AI to detect deepfake videos
• tbh (acquired by Facebook): Positive feedback app for teens

Cost-Saving Medical Technologies

• Sepsis Scout (acquired by Cytovale): Early sepsis detection via deep learning
• Persephone Biome  Synthetic fecal transplants as cancer therapy
• Pelago Health  AI-powered Cognitive Beahvioral Therapy for addiction
• Spect  Cheap AI disease diagnosis via smartphone eye scans
• Lunar Health  AI-native EHR that prevents medical errors

Venture Capital Funds

• Atypical Ventures, LP: Plausible science fiction
• Remote First Capital, LP: Future of work
• Tenacity Venture Capital, LP: Startups that refuse to die

Note: Roughly one-third of my investments are in female-led startups and half in companies led by non-white CEOs. That wasn’t a strategy — it just happened.